2. Attention-getting Cross Infections: Extended-spectrum Beta-lactamase-producing Bacterial Infections

Community-acquired urinary tract infections by extended-spectrum beta-lactamase-producing Gram negative bacteria

Antibiotic resistance among uropathogens causing community acquired urinary tract infection (CAUTI) is increasing worldwide. Severity and endemicity persists despite of wide spread availability of drugs. Knowledge of the aetiology and antimicrobial susceptibility patterns of uropathogens is important in order to determine the best empiric treatment option. Extended-spectrum beta-lactamase (ESBL...

Impact of extended spectrum beta-lactamase producing Klebsiella pneumoniae infections in severely burned patients.

BACKGROUND Significantly higher mortality has been demonstrated in patients who suffer severe burns complicated by Klebsiella pneumoniae bacteremia. The specific virulence mechanisms associated with this organism in this population are unclear. STUDY DESIGN Our study assessed the impact of the mechanism of antibiotic resistance, strain clonality, and other host factors on morbidity and mortal...

A change in the epidemiology of infections due to extended-spectrum beta-lactamase-producing organisms.

Extended-spectrum beta-lactamase-producing organisms.

Extended-spectrum beta-lactamases (ESBLs), which hydrolyse extended-spectrum cephalosporins and are inhibited by clavulanic acid, are spreading among Enterobacteriaceae. The CTX-M enzymes are replacing SHV and TEM enzymes as the prevalent type of ESBLs, principally in community-acquired infections caused by Escherichia coli. Associated infectious syndromes include mainly urinary tract infection...

Management of Extended-Spectrum Beta-Lactamase-Positive Gram-Negative Bacterial Urologic Infections

Extended-spectrum beta-lactamases (ESBLs) are enzymes that confer increased resistance to commonly used antibiotics. The prevalence rates of ESBL producing bacteria are increasing, and the associated increase in morbidity and mortality is becoming a public health concern. ESBL producers are emerging as an important cause of urinary tract infection (UTI) and empirical therapy should therefore be...